Mechanism of action
Ultram is an opioid medication and like other opioid drugs, selectively attach to various opiate receptors in your central nervous system. CYP2D6, the liver enzyme, converts tramadol into M1, its active metabolite that strongly binds to the mu receptor as compared with its inactive form. However, Tramadol does not attach to the mu receptor like morphine. Unlike other opioid drugs, Tramadol does not completely revere its course post the administration of Naloxone. Together with the partial agonist activity on the opioid receptors, it inhibits the reuptake of norepinephrine and serotonin.
Tramadol is available in two different formulations – namely immediate-release and extended-release. Both, the immediate-release as well as extended-release come in the form of capsules. In the case of extended-release, patients should be counseled on the drug. You should not crush, spit, chew or dissolve it prior to administration. You may ingest both the formulations either with or without food, but the extended-release formula should be taken at around the same time every day.
The half-life of this medicine is around six hours. The extended-release formulation of the drug may hit the peak concentration in twelve hours. On the other hand, the immediate-release formulation of the medicine may hit the peak in 1.6 to 1.9 hours. The extended-release formulation is available in the strength of 100 mg, 200 mg and 300 mg. The immediate-release formulation of the medicine is in the strength of 50 mg.
What are the contraindications of taking Ultram?
This drug is contraindicated in individuals who have had a hypersensitivity reaction to any opioid medication. Individuals below the age of twelve years should not take this drug and people under the age of eighteen years should not ingest this medicine in case they suffer from a history of adenoidectomy or tonsillectomy. Since Tramadol may produce respiratory depression, individuals with a history of bronchial asthma or serious respiratory depression without necessary equipment should not take this medicine.
Moreover, people presently on MOAs or who have been on MOAs in the past fortnight should not be administered Ultram. Individuals on tricyclic antidepressants should also not be given this drug. Further people with GI obstruction should not be administered this drug. Order Ultram Online to prevent the occurrence of the symptoms of pain.